Radicle ACES is the first multi-brand, Institutional Review Board-approved randomized controlled trial to evaluate the effectiveness of commercially available CBD products. We recruited 3000 participants from across the United States who reported symptoms of anxiety, sleep disturbance, or long-term pain, and randomized them to receive a 4-week supply of 1 of 13 different commercially available CBD products, or to receive no product until the end of the study (i.e., waitlist control).